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In vivo endoscopic optical coherence elastography based on a miniature probe.

Haoxing Xu1,2, Qingrong Xia1,3,4, Chengyou Shu1

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This study introduces the first endoscopic optical coherence elastography (OCE) system for in vivo elasticity imaging. The miniaturized system enables precise, high-resolution assessment of tissue biomechanics, advancing diagnostic capabilities.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Biophysics

Background:

  • Optical coherence elastography (OCE) extends optical coherence tomography (OCT) for high-resolution tissue elasticity assessment.
  • Current limitations in endoscopic OCE include probe size, excitation efficiency, and speed for in vivo applications.

Purpose of the Study:

  • To develop and demonstrate the first in vivo endoscopic OCE system.
  • To overcome challenges in probe miniaturization and improve excitation efficiency for endoscopic elasticity imaging.

Main Methods:

  • Development of a novel endoscopic OCE system with a 0.9 mm integrated probe.
  • Utilized a 38-MHz high-frequency ultrasound transducer for rapid tissue deformation induction.
  • Validated accuracy using phantom studies comparing OCE results with compression testing.

Main Results:

  • Achieved the first successful in vivo endoscopic OCE imaging.
  • Phantom studies demonstrated high quantification accuracy comparable to compression testing.
  • In vivo rat vaginal imaging precisely distinguished normal tissue, hematomas, and fibrotic tissue based on elasticity.

Conclusions:

  • The developed endoscopic OCE system successfully performs in vivo elasticity imaging.
  • This technology significantly advances the potential for early diagnosis of intraluminal diseases.
  • The system's miniaturization and accuracy pave the way for clinical translation of endoscopic OCE.