Related Experiment Video
Updated: Jun 20, 2025
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Current research status and future prospects of NLRP3 inflammasome in cardiovascular diseases: a bibliometric and
Meiqi Miao1, Yuanyuan Yang2, Hailong Dai3
1Department of Cardiology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Insights
Research on the NLRP3 inflammasome in cardiovascular disease (CVD) is growing, with key mechanisms including oxidative stress and pyroptosis. Emerging trends focus on cholesterol markers and inflammatory indicators for CVD risk assessment.
Area of Science:
- Biomedical Sciences
- Immunology
- Cardiology
Background:
- Cardiovascular disease (CVD) is a major cause of mortality, with atherosclerosis (AS) as a key pathological basis.
- Inflammation is critical in AS pathophysiology, and the NOD-like receptor protein 3 (NLRP3) inflammasome is a significant focus of research.
Purpose of the Study:
- To analyze the current research status of the NLRP3 inflammasome in cardiovascular disease.
- To identify research hotspots and emerging trends.
- To provide directions for future research in this field.
Main Methods:
- Bibliometric analysis of 516 articles published between 2012-2023 from the Web of Science database.
- Keywords used: "CVD" OR "cardiovascular disease" AND "NLRP3 inflammasome" OR "NLRP3".
- Analysis using "Bibliometrix" and "CiteSpace" software, examining authors, countries, institutions, journals, keywords, and references.
Main Results:
- Annual publication volume shows an upward trend.
- China, the United States, and Europe are leading regions in publications; the US leads in citations and influence.
- Key pathogenic mechanisms include oxidative stress, pyroptosis, and inflammation; NF-κB, IL-1, and C-reactive protein are frequently studied pathways. Coronary heart disease, atherosclerosis, metabolic syndrome, and myocardial infarction are primary research areas. Emerging focus on cholesterol markers and inflammatory indicators (NLRP3/IL-6/hs-CRP) for CVD risk.
Conclusions:
- The study offers valuable insights into research hotspots and trends concerning the NLRP3 inflammasome in CVD.
- Findings guide researchers and scholars, facilitating the exploration of novel research avenues in this domain.
Background:
Cardiovascular disease (CVD) is a leading cause of global mortality, with atherosclerosis (AS) contributing to its pathological basis. Inflammation plays a critical role in the pathophysiological process of AS, and the NOD-like receptor protein 3 (NLRP3) inflammasome has been extensively studied in this context. This study aimed to analyze the research status of the NLRP3 inflammasome in cardiovascular disease and provide research directions for further exploration in this field.
Methods:
Using the "Bibliometrix" and "CiteSpace" software, a total of 516 articles were retrieved from the Web of Science (WoS) database published between 2012 and 2023. The search query used the keywords "["CVD" OR "cardiovascular disease"] AND ["NLRP3 inflammasome "OR "NLRP3"]". Visual analysis was performed on authors, countries, institutions, journal sources, keywords, references, and future trends.
Results:
A total of 516 English articles were retrieved, showing an overall upward trend in annual publication volume with slight fluctuations. China, the United States, and Europe were the countries and regions with the highest number of published articles. Among them, China had the highest article count (170), while the United States had the highest citation count (18,664), centrality score (0.43), and h-index (90), indicating its influential role in this research area. These countries also possessed elite institutions, professional researchers, and high-impact journals, making them leading contributors in this field. The main pathogenic mechanisms of the NLRP3 inflammasome in CVD were identified as "oxidative stress", "pyroptosis", and "inflammation". The most frequently studied signaling pathways included "NF-κB", "IL-1", and "C-reactive protein". The most studied disease types were coronary heart disease, atherosclerosis, metabolic syndrome, and myocardial infarction. Additionally, research on the correlation between cholesterol markers and inflammatory indicators associated with NLRP3 inflammasome in CVD risk assessment has gained significant momentum, with the main mechanism being NLRP3/IL-6/hs-CRP and cholesterol lipoproteins emerging as a major keyword in this context.
Conclusion:
This study provides valuable insights into the research hotspots and emerging trends of the NLRP3 inflammasome in cardiovascular disease. The findings offer guidance for researchers and scholars in this field and facilitate the exploration of new research directions.
More Related Videos
06:52Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
09:43In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
Published on: August 4, 2011
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:38Inflammation
02:26NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...