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Updated: Jun 20, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
Rare inherited coagulation disorders: no longer orphan and neglected
Samin Mohsenian1, Pier Mannuccio Mannucci2, Marzia Menegatti2
1Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Abstract:
Rare inherited coagulation disorders due to the deficiency or dysfunction of coagulation factors have until recently received less clinical attention than hemophilias and von Willebrand disease. This situation has changed in the last decades, mainly due to therapeutic progress with the availability of more and safer products for replacement therapy produced by plasma fractionation or recombinant DNA technology. This narrative review, based on the latest literature and expert opinion, emphasizes the progress achieved for each of the rare deficiencies, mentions the still unmet therapeutic needs, and sketches the perspectives for further progress.
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