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The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

Alireza Mafi1,2, Neda Hedayati3, Samaneh Kahkesh4

  • 1Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Non-Coding RNA Research
|July 18, 2024
PubMed

Insights

Circular RNAs (circRNAs) are linked to temozolomide (TMZ) resistance in glioma. Targeting circRNAs may offer new strategies to overcome drug resistance and improve glioma treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gliomas are aggressive primary brain tumors with significant global health impact.
  • Circular RNAs (circRNAs) are emerging as key players in cancer development and progression.
  • Dysregulation of specific circRNAs is increasingly associated with temozolomide (TMZ) resistance in glioma.

Purpose of the Study:

  • To review the biological characteristics of circRNAs in glioma.
  • To explore the role of circRNAs in mediating temozolomide (TMZ) resistance.
  • To identify potential therapeutic strategies targeting circRNAs for overcoming TMZ resistance in gliomas.

Main Methods:

  • Literature review of recent studies on circRNAs and glioma.
  • Analysis of circRNA involvement in molecular pathways related to drug resistance.
  • Summary of circRNA's potential role in signaling pathways (e.g., Ras/Raf/ERK, PI3K/Akt) and metabolic processes.

Main Results:

  • Specific circRNA dysregulations are clinically linked to temozolomide (TMZ) resistance in glioma.
  • CircRNAs can influence molecular pathways crucial for drug resistance.
  • CircRNAs are implicated in modulating metabolic processes within glioma cells.

Conclusions:

  • CircRNAs represent promising biomarkers for glioma diagnosis and prognosis.
  • Targeting circRNAs offers a potential therapeutic avenue to overcome temozolomide (TMZ) resistance.
  • CircRNA-based strategies could lead to novel, individualized glioma therapies.
Keywords:
Drug resistanceGliomaMolecular mechanismsTemozolomide (TMZ)Therapeutic targetscircRNAs

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