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The interregulatory circuit between non-coding RNA and apoptotic signaling in diabetic cardiomyopathy

Hao Wu1, Yan Liu1, Chunli Liu1

  • 1Public Health Clinical Center Affiliated to Shandong University, Jinan, 250100, China.

Non-Coding RNA Research
|July 18, 2024
PubMed

Insights

Diabetes and diabetic cardiomyopathy (DCM) involve programmed cell death (apoptosis). This review explores how non-coding RNAs (ncRNAs) interact with apoptosis in DCM, crucial for developing new treatments.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Genetics

Background:

  • Diabetes mellitus is a growing epidemic, increasing cardiovascular disease risk.
  • Diabetic cardiomyopathy (DCM) is a serious complication of diabetes.
  • Apoptosis, or programmed cell death, is involved in DCM development.

Purpose of the Study:

  • To review apoptotic signaling pathways in DCM.
  • To explore the reciprocal regulation between apoptosis and non-coding RNAs (ncRNAs) in DCM.
  • To enhance understanding and therapeutic strategies for DCM.

Main Methods:

  • Literature review of apoptotic pathways in DCM.
  • Analysis of the role of ncRNAs in gene expression and cellular processes.
  • Examination of the interplay between ncRNAs and apoptosis in cardiac tissue.

Main Results:

  • ncRNAs play significant roles in regulating gene expression, proliferation, and apoptosis.
  • Aberrant ncRNA expression is implicated in DCM progression.
  • ncRNAs and apoptosis mutually influence cardiac tissue fate in DCM.

Conclusions:

  • Understanding the interplay between ncRNAs and apoptosis is vital for DCM management.
  • Targeting ncRNA-apoptosis interactions may offer novel therapeutic avenues for DCM.
  • This review provides insights into DCM pathogenesis and potential treatment strategies.

Keywords:
ApoptosisDiabetic cardiomyopathyNon-coding RNAs

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