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Translocation of Proteins into the Mitochondria

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Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
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Related Experiment Video

Updated: Jun 20, 2025

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

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Published on: September 28, 2019

The reciprocal relationship between amyloid precursor protein and mitochondrial function.

Taylor A Strope^1,2, Heather M Wilkins^1,2,3

¹University of Kansas Alzheimer's Disease Research Center, Kansas City, Kansas, USA.

Journal of Neurochemistry

|July 18, 2024

Summary

Alzheimer

Keywords:

Alzheimer's disease amyloid beta amyloid precursor protein mitochondria γ‐Secretase

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Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

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Published on: January 10, 2025

Area of Science:

Neuroscience
Cell Biology
Biochemistry

Background:

Alzheimer's disease (AD) involves amyloid precursor protein (APP) and amyloid beta (Aβ).
The precise roles of APP, secretase enzymes, and their metabolites in AD pathogenesis remain unclear.
These proteins and their processing products are found in cellular organelles, including mitochondria.

Purpose of the Study:

To review the literature on the functions of APP, secretase enzymes, and APP metabolites.
To explore their roles in mitochondrial function and bioenergetics within the context of AD.
To identify knowledge gaps and limitations in current research.

Main Methods:

Literature review of studies on APP processing and mitochondrial function in AD.
Analysis of protein localization data (endosomes, mitochondria, ER).
Synthesis of findings linking APP metabolism to mitochondrial dysfunction and proteostasis.

Main Results:

APP, secretases, and Aβ are localized to mitochondria and ER-mitochondrial contact sites.
Significant links exist between APP metabolism and mitochondrial function.
Mitochondrial dysfunction is a hallmark of AD, connected to proteostasis.

Conclusions:

APP, secretase enzymes, and Aβ metabolites play roles in mitochondrial function and bioenergetics.
Understanding these interactions is crucial for elucidating AD pathogenesis.
Further research is needed to address knowledge gaps in this field.