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Validation of the HeartMate 3 survival risk score in a large left ventricular assist device center

Cathrine M Moeller1, Gal Rubinstein1, Daniel Oren1

  • 1Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.

The Journal of Thoracic and Cardiovascular Surgery
|July 18, 2024
PubMed

Insights

The HeartMate 3 survival risk score predicted mortality in left ventricular assist device patients. While not an independent predictor after adjustments, it identified high-survival patients using a binary cutoff.

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Outcomes

Background:

  • The HeartMate 3 survival risk score was developed to predict patient-specific survival for HeartMate 3 left ventricular assist device candidates.
  • This score stratifies patients into tertiles based on their predicted survival probability.

Purpose of the Study:

  • To validate the HeartMate 3 survival risk score in a real-world patient cohort.
  • To assess the score's ability to predict survival in patients receiving the HeartMate 3 left ventricular assist device.

Main Methods:

  • A retrospective review of 181 HeartMate 3 left ventricular assist device recipients was conducted.
  • Survival analyses utilized Kaplan-Meier methods and Cox regression models.
  • HeartMate 3 survival risk scores were calculated for all eligible patients.

Main Results:

  • The unadjusted HeartMate 3 survival risk score was a significant predictor of mortality.
  • Two-year survival rates varied across risk groups, with the high-risk group showing 93.5% survival.
  • The score identified high-survival patients using a binary cutoff, though discrimination across tertiles was not demonstrated.

Conclusions:

  • The HeartMate 3 survival risk score is associated with postimplant survival but is not an independent predictor when adjusted for specific comorbidities.
  • The score can identify high-survival patients effectively using a binary cutoff.
  • The score's discriminatory ability across previously defined risk tertiles was not confirmed in this cohort.
Abstract

Keywords:
HeartMate 3HeartMate 3 survival risk scoreleft ventricular assist devicepredictionvalidation

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