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  11. Expression And Analysis Of Cx3cl1 Chemokine And Cd57+ Lymphocytes In Oral Squamous Cell Carcinoma And Their Correlation With Clinicopathologic Features

Expression and analysis of CX3CL1 chemokine and CD57+ lymphocytes in oral squamous cell carcinoma and their correlation with clinicopathologic features

Shivani Singh1, Aadithya B Urs2, Priya Kumar2

  • 1Department of Radiation Oncology, Maulana Azad Medical College, New Delhi, India.

Journal of Cancer Research and Therapeutics
|July 18, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Chemokine CX3CL1 and CD57+ cells are crucial for antitumor immunity in oral squamous cell carcinoma (OSCC). Their expression decreases with higher tumor grade, suggesting a role in immune surveillance.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Chemokine CX3CL1 (fractalkine) attracts immune cells like T-cells, monocytes, and natural killer (NK) cells, contributing to antitumor immunity.
  • Previous studies have explored CX3CL1's role in various cancers, but its significance in oral squamous cell carcinoma (OSCC) remains less understood.

Purpose of the Study:

  • To investigate the expression and correlation of CX3CL1 and CD57+ cells in oral squamous cell carcinoma (OSCC).
  • To understand the potential role of CX3CL1 and CD57 in the immune surveillance of OSCC.

Main Methods:

  • Seventy-five primary OSCC samples were analyzed using immunohistochemistry for CX3CL1 and CD57.
  • Statistical analysis included Mann-Whitney U-test, Kruskal-Wallis test, Bonferroni test, and Pearson's correlation coefficient.

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Main Results:

  • High expression of CX3CL1 was observed in 62.66% of OSCC cases.
  • A significant inverse correlation was found between the expression of both CX3CL1 and CD57 and increasing histologic grade of OSCC (p = 0.021 and 0.038).

Conclusions:

  • CX3CL1 and CD57 are implicated as important components in the immune surveillance of OSCC.
  • Further research is warranted to elucidate the diagnostic, prognostic, and therapeutic potential of CX3CL1 in OSCC, including patient survival studies.