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Related Experiment Videos

Potential uses for metoclopramide.

A F Shaughnessy

    Drug Intelligence & Clinical Pharmacy
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Metoclopramide, a dopamine antagonist, shows potential for treating tardive dyskinesia, reducing aspiration risk, and managing gastric bezoars. Further research is needed for other investigated conditions.

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    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Neurology

    Background:

    • Metoclopramide is a U.S.-approved dopamine antagonist for gastrointestinal disorders.
    • Its therapeutic applications extend beyond the gastrointestinal tract, prompting broader investigation.
    • Understanding the full spectrum of metoclopramide's efficacy and safety is crucial.

    Purpose of the Study:

    • To review the current evidence for metoclopramide's use in various medical conditions.
    • To identify potential new therapeutic indications for metoclopramide.
    • To assess the need for further research in specific patient populations.

    Main Methods:

    • Literature review of studies investigating metoclopramide's efficacy.
    • Analysis of clinical data for conditions beyond primary gastrointestinal indications.

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  • Evaluation of safety profiles in diverse patient groups.

    • Main Results:

    • Metoclopramide may be effective for tardive dyskinesia, reducing anesthetic-related aspiration risk, and treating gastric bezoars.
    • Safe use in Parkinson's disease patients is noted.
    • Evidence is insufficient to support use in neurogenic bladder, orthostatic hypotension, gastroparesis, amenorrhea, failure to thrive, Tourette's syndrome, anorexia nervosa, hiccups, or as migraine adjunct.

    Conclusions:

    • Metoclopramide demonstrates promise in specific neurological and gastrointestinal conditions.
    • Its application in several other disorders requires more robust clinical evidence.
    • Further research is warranted to establish definitive treatment guidelines for metoclopramide in expanded indications.