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The potential roles of PKM2 in cerebrovascular diseases

Ling Ma1, Huatao Li2, Hu Xu3

  • 1Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.

International Immunopharmacology
|July 18, 2024
PubMed

Insights

Pyruvate kinase M2 (PKM2) is crucial for cell metabolism and has emerged as a key player in cerebrovascular diseases (CeVDs). Understanding PKM2

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Neuroscience

Background:

  • Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme regulating cell metabolism and growth.
  • Cerebrovascular diseases (CeVDs) involve disturbances in intracranial blood circulation and are linked to oxidative stress, inflammation, and mitochondrial dysfunction.

Purpose of the Study:

  • To review the characteristics of PKM2.
  • To summarize the regulated expression of PKM2.
  • To elucidate the biological roles of PKM2 in cerebrovascular diseases.

Main Methods:

  • Literature review of studies on PKM2 and CeVDs.
  • Analysis of PKM2's involvement in cellular metabolism, oxidative stress, inflammation, and mitochondrial dynamics.
  • Examination of PKM2 isoforms, expression levels, subcellular localization, and post-translational modifications.

Main Results:

  • PKM2 plays a significant role in regulating energy supply, oxidative stress, inflammatory responses, and mitochondrial dysfunction in CeVDs.
  • PKM2's functions are modulated by its isoforms, expression patterns, subcellular localization, and post-translational modifications.

Conclusions:

  • Summarizing PKM2's roles in CeVDs enhances understanding of the molecular mechanisms underlying these conditions.
  • Further research into PKM2 could reveal novel therapeutic targets for cerebrovascular diseases.
Keywords:
Cerebrovascular diseasesMitochondriaPKM2Post-translational modificationROS

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