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Cellular immunotherapies and immune cell depleting therapies in inflammatory bowel diseases: the next magic bullet?

Markus Friedrich Neurath1, Bruce Eric Sands2, Florian Rieder3

  • 1Department of Medicine 1, Kussmaul Research Campus & Ludwig Demling Endoscopy Center of Excellence, Deutsches Zentrum Immuntherapie DZI, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany markus.neurath@uk-erlangen.de.

Gut
|July 18, 2024
PubMed

Despite significant advances in biologic and small molecule treatments and the emergence of combination therapies to treat inflammatory bowel diseases (IBD) a large unmet need remains to control intestinal inflammation. New approaches targeting several pathways simultaneously with a favorable safety profile and agents that trigger anti-inflammatory pathways to drive durable resolution of inflammation are needed. This article discusses novel cellular immunotherapies and immune cell depleting therapies in IBD, including CAR-T cell approaches, Tr1 and T regulatory (Treg) cells and cell depleting antibodies such as rosnilimab. These novel approaches have the potential to overcome current therapeutic limitations in the treatment of IBD.

Keywords:
CELLULAR IMMUNOLOGYIBD CLINICAL

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