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Related Experiment Video

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StepBrain: A 3-Dimensionally Printed Multicompartmental Anthropomorphic Brain Phantom to Simulate PET Activity

Maria Agnese Pirozzi1, Valeria Gaudieri2, Anna Prinster3

  • 1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy; mariaagnese.pirozzi@unicampania.it.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|July 18, 2024
PubMed
Summary

A novel 3D-printed brain phantom, StepBrain, accurately simulates in vivo tracer uptake in brain regions. This tool aids in validating Positron Emission Tomography (PET) studies and harmonizing multicenter research.

Keywords:
18F-FDG3D printingPET/CTanthropomorphic brain phantom

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Biomedical Engineering

Background:

  • Current brain phantoms have limitations in simulating in vivo tracer uptake.
  • Accurate simulation of tracer distribution is crucial for Positron Emission Tomography (PET) studies.
  • Standardization is needed for multicenter PET harmonization.

Purpose of the Study:

  • To introduce StepBrain, an innovative multicompartmental anatomic brain phantom.
  • To overcome limitations of existing phantoms in simulating in vivo tracer uptake.
  • To enable realistic simulation of PET brain studies for various tracers.

Main Methods:

  • Utilized fused deposition modeling 3D printing to replicate brain anatomy from healthy volunteer MR images.
  • Created a multicompartmental phantom (StepBrain) for gray matter, white matter, and striatum.
  • Simulated 18F-FDG PET studies with controlled activity concentrations.

Main Results:

  • Achieved realistic simulation of 18F-FDG PET brain studies.
  • Confirmed accuracy in recovering target activity concentrations using partial-volume effect correction tools.
  • Demonstrated StepBrain's ability to simulate different tracer distributions (e.g., amyloid, tau, 6-fluoro-l-dopa).

Conclusions:

  • StepBrain compartments can be simultaneously filled with varying concentration ratios.
  • The phantom facilitates the simulation of diverse tracer distributions.
  • StepBrain holds potential value for multicenter PET harmonization studies.