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A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation
Published on: April 24, 2020
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Wide-energy programmable microwave plasma-ionization for high-coverage mass spectrometry analysis
Fengjian Chu1,2, Gaosheng Zhao3, Wei Wei2
1College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.
Nature Communications
|July 18, 2024
Summary
A new wide-energy programmable microwave plasma-ionization mass spectrometry (WPMPI-MS) system offers broad analyte coverage. This versatile mass spectrometry technique enables rapid, simultaneous detection of diverse compounds in various real-world samples.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
- Plasma Physics
Background:
- Existing ambient ionization mass spectrometry techniques lack comprehensive analyte coverage.
- A universal ion source for diverse analytical challenges remains elusive.
Purpose of the Study:
- To introduce a novel wide-energy programmable microwave plasma-ionization mass spectrometry (WPMPI-MS) system.
- To demonstrate its capability for high-coverage analysis of various substances.
Main Methods:
- Digital regulation of microwave energy for broad substance analysis.
- Rapid scanning of ionization energy using programmable waveforms.
- Application of WPMPI-MS to real samples like serum, soil, pharmaceuticals, and leachate.
Main Results:
- Achieved high coverage of substances with diverse characteristics.
- Enabled simultaneous detection of biomolecules, heavy metals, and non-polar molecules in seconds.
- Demonstrated robust quantification and liquid chromatography coupling capabilities in serum analysis.
Conclusions:
- WPMPI-MS offers a versatile solution for analyzing a wide range of analytes.
- The system shows strong performance in complex real-world sample matrices.
- WPMPI-MS is a promising alternative to existing commercial ion sources for broad chemical and biological analysis.
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