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Predictive role of PAR and LAR in refractory suppurative meningitis in infants

YaSong Gao1, FangQi Hu2

  • 1Department of Pediatrics, Anqing Municipal Hospital, Anqing, Anhui, 246000, China.

BMC Pediatrics
|July 18, 2024
PubMed
Abstract

Insights

Platelet/albumin (PAR) and lactate dehydrogenase/albumin (LAR) show promise for diagnosing refractory suppurative meningitis in infants. Lower PAR indicates a protective factor, while higher LAR suggests a risk factor for poor prognosis.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Biomarkers

Background:

  • Suppurative meningitis presents atypical symptoms in infants, complicating early diagnosis and treatment.
  • Novel inflammatory biomarkers, Platelet/Albumin ratio (PAR) and Lactate Dehydrogenase/Albumin ratio (LAR), have shown potential in various conditions.
  • Investigating these biomarkers in pediatric meningitis could improve diagnostic accuracy.

Purpose of the Study:

  • To evaluate the diagnostic utility of PAR and LAR in identifying refractory suppurative meningitis in infants.
  • To compare PAR and LAR levels between common and refractory meningitis cases in children.
  • To determine the prognostic value of PAR and LAR in pediatric suppurative meningitis.

Main Methods:

  • Retrospective analysis of clinical data from 107 children diagnosed with suppurative meningitis.
  • Classification of patients into common (82 cases) and refractory (25 cases) groups based on disease severity.
  • Comparison of clinical and laboratory findings, including PAR and LAR, between the two groups, with multivariate Logistic regression analysis.

Main Results:

  • Children with refractory meningitis exhibited significantly lower PAR levels and higher LAR levels compared to the common group (P<0.05).
  • Multivariate analysis identified LAR as a risk factor (OR>1, P<0.05) and PAR as a protective factor (OR<1, P<0.05) for poor prognosis.
  • Low cerebrospinal fluid glucose (≤1.5 mmol/L) was also identified as a risk factor for poor outcomes.

Conclusions:

  • PAR and LAR serve as valuable biomarkers for the early diagnosis of refractory suppurative meningitis in children.
  • PAR acts as a protective factor, while LAR is a risk factor, aiding in prognosis assessment.
  • These novel biomarkers can assist clinicians in differentiating disease severity and predicting outcomes in pediatric meningitis.
Keywords:
Lactate dehydrogenase/AlbuminPlatelet/albuminSuppurative meningitis

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