Related Experiment Video
Updated: Jun 20, 2025
08:09
Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
Published on: February 11, 2017
11.5K
Emotional and behavioural functioning in children with tyrosinaemia type 1
Monika Pohorecka1, Marcin Biernacki2, Anna Jakubowska-Winecka3
1Clinical Department of Pediatrics and Allergology, National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland.
Pediatric Endocrinology, Diabetes, and Metabolism
|July 19, 2024
Summary
Fluctuations in phenylalanine levels in tyrosinaemia type I patients correlate with emotional and behavioral issues. Managing these levels may improve quality of life and development.
Area of Science:
- Metabolic disorders
- Neurodevelopmental disorders
- Pediatric psychology
Background:
- Tyrosinaemia type I is a rare hereditary metabolic disease.
- Nitisinone treatment has improved survival but revealed socio-emotional challenges.
- Understanding the impact of metabolic control on behavior is crucial.
Purpose of the Study:
- To assess the relationship between serum tyrosine and phenylalanine levels and socio-emotional functioning.
- To determine the intelligence quotient (IQ) of patients with tyrosinaemia type I.
- To identify factors influencing behavioral outcomes in treated patients.
Main Methods:
- Study included 12 children with tyrosinaemia type I treated with nitisinone and diet.
- Psychological evaluation used the Child Behaviour Checklist (CBCL)/4-18.
- Intelligence was measured using the Stanford-Binet 5 (SB5) Intelligence Scale.
Main Results:
- Phenylalanine variability correlated with emotional and behavioral functioning, particularly externalizing behaviors.
- Externalizing behaviors were associated with maladjustment and aggression.
- All patients demonstrated intellectual and cognitive function within the normal range.
Conclusions:
- Avoiding significant phenylalanine level fluctuations may enhance quality of life.
- Regular psychological evaluations are recommended for early detection and intervention.
- Optimizing development and potential requires managing metabolic control and behavior.
More Related Videos
13:08Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
8.9K
05:32Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
Published on: December 7, 2018
8.9K
Related Concept Videos
01:30Attention-Deficit/Hyperactivity Disorder
51
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
51
01:30Socioemotional Development during Infancy
53
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
53
01:28Human Genetics
556
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
556
01:20Inborn Errors of Metabolism
153
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
153
01:30Bipolar Disorder
63
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
63
01:29Personality Theory by Eysenck and Eysenck
431
Hans and Sybil Eysenck developed a widely recognized theory of personality, which emphasizes the role of temperament and genetically based differences in shaping individual traits. Their theory posits that biological factors primarily determine personality and can be understood through two main dimensions: extroversion/introversion and neuroticism/stability.
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
431