Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

915
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
915
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

163
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
163

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistently increased frequency of diabetic ketoacidosis in new-onset type 1 diabetes in Polish children: nationwide analysis 2019-2022.

Frontiers in endocrinology·2026
Same author

Decoding Inflammation in Hidradenitis Suppurativa: Serum Cytokines as Biomarkers of Disease Severity and Treatment Outcome-Systematic Review.

Journal of clinical medicine·2026
Same author

The role of the skin microbiome in modulating rosacea.

Postepy dermatologii i alergologii·2026
Same author

Automated insulin delivery use in children and adolescents with type 1 diabetes across the world.

Diabetes research and clinical practice·2026
Same author

INNODIA screening for early-stage type 1 diabetes: Insights from Polish first-degree relatives of T1D patients (2015-2023, EU115797).

Advances in clinical and experimental medicine : official organ Wroclaw Medical University·2026
Same author

Multicenter screening for ADHD among school-age pediatric patients with type 1 diabetes - study protocol.

Nordic journal of psychiatry·2025

Related Experiment Video

Updated: Jun 20, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.8K

Less common forms of diabetes in young population.

Anna Tekielak1, Ewa Otto-Buczkowska2, Ewa Rusak3

  • 1Students' Scientific Association at the Department of Children's Diabetology, Medical University of Silesia, Katowice, Poland.

Pediatric Endocrinology, Diabetes, and Metabolism
|July 19, 2024
PubMed
Summary

Type 2 diabetes and Maturity-Onset Diabetes of the Young (MODY) are increasingly diagnosed in children and adolescents. Early intervention focusing on insulin resistance and lifestyle changes is crucial for managing these conditions.

Keywords:
maturity-onset diabetes of the young (MODY)oral antidiabetic agentstype 2 diabetesyouth-onset non-insulin-dependent diabetes mellitus (NIDDM-Y)insulin resistance

More Related Videos

Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.4K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.1K

Related Experiment Videos

Last Updated: Jun 20, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.8K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.4K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.1K

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Type 1 diabetes is the most common form in youth, but other types are emerging.
  • Type 2 diabetes incidence has risen dramatically in adolescents, linked to obesity.
  • Maturity-Onset Diabetes of the Young (MODY) is an inherited form caused by beta-cell defects.

Purpose of the Study:

  • To characterize and present non-Type 1 diabetes types in the pediatric population.
  • To highlight the increasing prevalence of Type 2 diabetes in youth.
  • To differentiate MODY from other forms of diabetes in young individuals.

Main Methods:

  • Review of epidemiological data on diabetes incidence in children and adolescents.
  • Analysis of the pathophysiology of Type 2 diabetes and MODY.
  • Comparison of clinical characteristics and genetic factors of different diabetes types.

Main Results:

  • Significant increase in Type 2 diabetes incidence in specific ethnic groups among adolescents.
  • Obesity and insulin resistance are key factors in Type 2 diabetes development.
  • MODY is characterized by autosomal dominant inheritance and impaired insulin secretion without significant insulin resistance.

Conclusions:

  • Diabetes types beyond Type 1, particularly Type 2 and MODY, require increased attention in pediatric care.
  • Lifestyle modifications and pharmacotherapy are essential for managing Type 2 diabetes in youth.
  • Understanding the distinct mechanisms of MODY is vital for appropriate diagnosis and management.