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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

504
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Related Experiment Video

Updated: Jun 20, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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Tertiary lymphoid structures: new immunotherapy biomarker.

Fangyuan Yang1, Jiahe Yang2, Meijuan Wu2

  • 1Department of Medical Oncology, Jinling Hospital, Nanjing Medical University, Nanjing, China.

Frontiers in Immunology
|July 19, 2024
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Summary

Tertiary lymphoid structures (TLSs) are key in predicting cancer immunotherapy success. These lymphocyte aggregations show promise as reliable biomarkers for treatment efficacy, especially in neoadjuvant settings.

Keywords:
biomarkercancercancer prognosisimmunotherapytertiary lymphoid structures

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Area of Science:

  • Oncology
  • Immunology
  • Biomarker Discovery

Background:

  • Immunotherapy represents a significant advancement in cancer treatment, increasingly adopted in clinical practice.
  • Current biomarkers for predicting immunotherapy efficacy often exhibit limited predictive power.
  • Tertiary lymphoid structures (TLSs), collections of lymphocytes within non-lymphoid tissues, are observed in various tumor types.

Purpose of the Study:

  • To review the characteristics and formation factors of Tertiary Lymphoid Structures (TLSs).
  • To present evidence on the role of TLSs in predicting immunotherapy response across different cancers.
  • To emphasize the potential of TLSs as predictive biomarkers for neoadjuvant immunotherapy.

Main Methods:

  • Comprehensive literature review of studies investigating Tertiary Lymphoid Structures (TLSs) in cancer.
  • Analysis of existing data correlating TLS presence and characteristics with immunotherapy outcomes.
  • Evaluation of TLSs as predictive markers in various oncological settings, including neoadjuvant therapy.

Main Results:

  • TLSs are present in diverse tumor tissues and have demonstrated correlations with patient prognosis.
  • Evidence suggests a significant association between TLSs and response to cancer immunotherapy.
  • TLSs show potential as predictive biomarkers for neoadjuvant immunotherapy efficacy.

Conclusions:

  • Tertiary Lymphoid Structures (TLSs) are emerging as promising biomarkers for predicting immunotherapy response.
  • Further research into TLSs could enhance personalized cancer treatment strategies.
  • TLSs hold significant potential for guiding neoadjuvant immunotherapy decisions.