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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jun 20, 2025

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
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Acute primary angle closure during the Omicron outbreak.

Dong Fang1, Wang-Ting Li1, Jia Liang1

  • 1Shenzhen Eye Hospital, Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, China.

International Journal of Ophthalmology
|July 19, 2024
PubMed
Summary
This summary is machine-generated.

The Omicron variant significantly increased acute primary angle closure (APAC) prevalence in China, with higher severity observed within three days of infection. This highlights a critical window for intervention in APAC patients during Omicron outbreaks.

Keywords:
Omicronacute primary angle closureocular symptoms

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Public Health

Background:

  • Acute primary angle closure (APAC) is a serious ophthalmic condition.
  • The Omicron variant of SARS-CoV-2 has led to widespread outbreaks globally.
  • Understanding the impact of viral infections on ocular conditions is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical presentation and prevalence of APAC during the Omicron pandemic in China.
  • To compare APAC cases during the Omicron wave with pre-pandemic periods.
  • To identify risk factors and clinical characteristics associated with APAC in Omicron-infected patients.

Main Methods:

  • A consecutive case series design with historical controls was employed.
  • Data from Shenzhen Eye Hospital during the Omicron pandemic (Dec 2022–Jan 2023) were compared to two pre-pandemic control groups (2019 and 2022).
  • Prevalence, demographic characteristics, glaucoma history, surgical rates, medical costs, and pupil diameter were analyzed.

Main Results:

  • APAC prevalence was significantly higher during the Omicron pandemic (23.43%) compared to control periods (7.87%–8.96%).
  • Omicron-infected patients exhibited a higher prevalence of APAC, lower glaucoma history, increased surgical rates, and larger pupil diameters.
  • Ocular symptoms in 83% of Omicron-infected patients occurred within 3 days of systemic symptom onset, with Omicron infection being the sole independent predictor of pupil diameter.

Conclusions:

  • The Omicron epidemic in China was associated with an increased prevalence and severity of APAC.
  • A critical period for APAC exacerbation is observed within the first three days following Omicron infection.
  • These findings underscore the need for heightened vigilance and prompt management of APAC during Omicron outbreaks.