Toll-Like receptor 3 genetic polymorphism in dengue encephalitis
Rajesh Verma1, Atul K Pandey2, Rajarshi Chakraborty1
1Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of Family Medicine and Primary Care
|July 19, 2024
Summary
The Toll-like receptor 3 (TLR3) Leu412Phe polymorphism is associated with an increased risk of dengue encephalitis. This TLR3 gene variant did not impact mortality outcomes in dengue patients.
Area of Science:
- Immunology
- Genetics
- Infectious Diseases
Background:
- Dengue is a significant vector-borne viral illness with varied human manifestations.
- Toll-like receptors (TLRs) are crucial for innate immunity against pathogens.
- TLR3 plays a key role in the immune response to flaviviruses like dengue.
Purpose of the Study:
- To investigate the association between TLR3 gene single nucleotide polymorphism (SNP) and dengue encephalitis (DE).
- To analyze genotype, allele, and haplotype distributions of TLR3 Leu412Phe polymorphism in DE patients.
- To determine the correlation between TLR3 polymorphism and clinical outcomes, including mortality.
Main Methods:
- A case-controlled observational study was conducted.
- Real-time polymerase chain reaction (PCR) was used to genotype the TLR3 Leu412Phe SNP.
- 29 DE patients were compared with 29 age- and sex-matched dengue patients without neurological complications.
Main Results:
- The mutant genotype Phe/Phe (TT) of TLR3 Leu412Phe polymorphism showed a significant association with DE (31.03% vs 6.8%, P=0.019).
- No statistically significant association was found for the heterozygous genotype (Leu/Phe-CT) or the mutant Phe allele (T).
- TLR3 gene polymorphism did not correlate with 1-month mortality outcomes.
Conclusions:
- The mutant TLR3 Leu412Phe polymorphism may increase susceptibility to DE in dengue-infected individuals within the Indian population.
- TLR3 polymorphism does not appear to influence mortality at one month post-infection.
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