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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible-light induced selenocyclization of 2-ethynylanilines under ambient conditions: simple FeBr3 as a
Binbin Huang1, Xinye Tang1, Jiawei Yuan1
1Faculty of Arts and Sciences/College of Education for the Future, Beijing Normal University, Zhuhai 519085, China. binbinhuang@bnu.edu.cn.
Abstract:
We report herein a visible-light induced, Fe-catalyzed selenocyclization of 2-ethynylanilines with diselenides under ambient conditions, employing ethyl acetate as a benign solvent with no stoichiometric additive required. The simple iron salt FeBr3 serves as both a photo-induced LMCT (Ligand-to-Metal Charge Transfer) catalyst and a Lewis acid catalyst to promote the desired transformation in a sustainable manner, enabling the facile synthesis of diverse 3-selenylindoles with extended substitution patterns. Moreover, gram-scale reactions and late-stage functionalization of bioactive molecules further highlight the synthetic practicality of this method.
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