Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis
Sean Wasserman1,2, Rosleine Antilus-Sainte3, Noha Abdelgawad4
1Institute for Infection and Immunity, St. George's, University of London, London, United Kingdom.
Antimicrobial Agents and Chemotherapy
|July 19, 2024
Abstract:
Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials.


