Learning Interpretable Brain Functional Connectivity via Self-Supervised Triplet Network With Depth-Wise Attention

Brain functional connectivity has been widely explored to reveal the functional interaction dynamics between the brain regions. However, conventional connectivity measures rely on deterministic models demanding application-specific empirical analysis, while deep learning approaches focus on finding discriminative features for state classification, having limited capability to capture the interpretable connectivity characteristics. To address the challenges, this study proposes a self-supervised triplet network with depth-wise attention (TripletNet-DA) to generate the functional connectivity: 1) TripletNet-DA firstly utilizes channel-wise transformations for temporal data augmentation, where the correlated & uncorrelated sample pairs are constructed for self-supervised training, 2) Channel encoder is designed with a convolution network to extract the deep features, while similarity estimator is employed to generate the similarity pairs and the functional connectivity representations, 3) TripletNet-DA applies Triplet loss with anchor-negative similarity penalty for model training, where the similarities of uncorrelated sample pairs are minimized to enhance model's learning capability. Experimental results on pathological EEG datasets (Autism Spectrum Disorder, Major Depressive Disorder) indicate that 1) TripletNet-DA demonstrates superiority in both ASD discrimination and MDD classification than the state-of-the-art counterparts, where the connectivity features in beta & gamma bands have respectively achieved the accuracy of 97.05%, 98.32% for ASD discrimination, 89.88%, 91.80% for MDD classification in the eyes-closed condition and 90.90%, 92.26% in the eyes-open condition, 2) TripletNet-DA enables to uncover significant differences of functional connectivity between ASD EEG and TD ones, and the prominent connectivity links are in accordance with the empirical findings, thus providing potential biomarkers for clinical ASD analysis.