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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Tumor deposits in thyroid carcinomas.

Merih Guray Durak1, Deniz Gokcay1, Serra Begum Emecen1

  • 1Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Medicine
|July 19, 2024
PubMed
Summary
This summary is machine-generated.

Tumor deposits (TDs) are newly identified in thyroid cancer, appearing more frequently in medullary thyroid carcinoma and women. Their presence indicates a more aggressive tumor behavior and poorer overall survival, highlighting their prognostic significance.

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Area of Science:

  • Oncology
  • Pathology
  • Cancer Research

Background:

  • Tumor deposits (TDs) are discontinuous neoplastic masses in the lymphatic drainage pathway.
  • TDs have demonstrated poor prognostic implications in various cancers.
  • The incidence and prognostic value of TDs in thyroid carcinoma remain understudied.

Purpose of the Study:

  • To investigate the incidence of tumor deposits (TDs) in thyroid carcinoma.
  • To determine the prognostic value of TDs in thyroid carcinoma cases.
  • To analyze the association of TDs with clinicopathological features and survival outcomes.

Main Methods:

  • Retrospective cohort study of 194 thyroid carcinoma cases with cervical lymph node sampling/dissection.
  • Reevaluation of cases for the presence of tumor deposits (TDs).
  • Statistical analysis to compare incidence and correlate TDs with clinicopathological factors and survival.

Main Results:

  • Tumor deposits (TDs) were detected in 54 (27.8%) of thyroid carcinoma patients.
  • TDs were significantly more common in medullary thyroid carcinoma (TMC) than papillary thyroid carcinoma (TPC) (55.6% vs 25.0%).
  • TDs were associated with larger tumor size, lymphatic invasion, extrathyroidal extension, distant metastasis, and reduced overall survival (OS).

Conclusions:

  • Tumor deposits (TDs) exist in thyroid carcinoma and are more prevalent in TMC.
  • The presence of TDs is linked to more aggressive tumor behavior and poorer prognosis.
  • TDs represent a significant prognostic marker in thyroid carcinoma, particularly impacting OS.