Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of liver enzyme abnormalities and tobacco exposure with unexplained recurrent spontaneous abortion risk: A case-control study.

The Journal of international medical research·2026
Same author

Pterostilbene ameliorates benzo[b]fluoranthene-induced lung injury by suppressing Toll-like receptor 4/nuclear factor kappa-B pathway and mitochondria-mediated apoptosis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Pathway-engineered Co-assembly of nanorod-nanosphere binary superlattices.

Chemical communications (Cambridge, England)·2026
Same author

Polarization reversal and ion-electron co-modulation in in-plane anisotropic AgVP<sub>2</sub>S<sub>6</sub> for multimodal image processing.

Nature communications·2026
Same author

Long-term low-dose nanoplastic exposure induces neurotoxicity with oxidative brain damage.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

Dynamic and cell-type specific transcriptional reprogramming underlies the floral transition in the maize shoot apical meristem.

Genome biology·2026

Related Experiment Video

Updated: Jun 20, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.0K

Association between gut microbiota and postpartum depression: A bidirectional Mendelian randomization study.

Yonghao Sun1, Cuifang Fan2, Di Lei2

  • 1Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.

Journal of Affective Disorders
|July 19, 2024
PubMed
Summary

This study explored the gut microbiota

Keywords:
Bidirectional Mendelian randomization studyCausal relationshipGut microbiotaInverse variance weightedPostpartum depression

More Related Videos

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.2K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K

Related Experiment Videos

Last Updated: Jun 20, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.0K
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.2K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K

Area of Science:

  • Microbiome Research
  • Mental Health Studies
  • Genetic Epidemiology

Background:

  • An association exists between gut microbiota and postpartum depression (PPD), but the causal link is unclear.
  • Previous empirical studies suggest a connection, necessitating further investigation into the directionality of this relationship.

Purpose of the Study:

  • To investigate the potential reciprocal causal relationship between gut microbiota composition and postpartum depression (PPD).
  • To identify specific bacterial taxa associated with the risk or protection against PPD.

Main Methods:

  • Utilized Mendelian randomization (MR) analysis on large-scale genome-wide association study (GWAS) data.
  • Included 18,340 gut microbiota samples and 67,205 PPD cases.
  • Employed inverse-variance weighted (IVW) method and sensitivity analyses (weighted median, MR Egger, PRESSO) for robust results.

Main Results:

  • Identified six bacterial characteristics significantly correlated with PPD risk.
  • Found protective effects on PPD from Ruminococcaceae UCG010, Veillonellaceae, and Clostridia.
  • Indicated detrimental effects on PPD from Alphaproteobacteria, Slackia, and NB1n, confirmed by sensitivity analyses.

Conclusions:

  • The MR analysis suggests a potential causal role for specific gut bacteria in the development of PPD.
  • Findings highlight specific bacterial taxa that may influence PPD risk.
  • Further research is needed to fully understand the gut microbiota's impact on PPD.