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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis
Aline Berger1, Raphael Machado Castilhos2, Zahinoor Ismail3
1Programa de Pós-Graduação em Ciências Médicas da Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
Introduction:
Neuropsychiatric symptoms may impact prognosis in individuals with mild cognitive impairment (MCI); however, data on frequency of psychotic symptoms are sparse.
Methods:
We searched MEDLINE, EMBASE, PsychoINFO from inception to June 2023. We included studies reporting patients with MCI prevalence of (delusions and/or hallucinations. Random effects model were performed to estimate the prevalence, and subgroup and meta-regression analyses were performed to explore heterogeneity.
Results:
Of 3145 records identified, 36 studies were included, enrolling 20,426 patients. Overall prevalence of hallucinations was 1.78 % (95 % CI, 1.17 - 2.71) and delusions 3.84 % (95 % CI, 2.71 - 5.42), both with significant heterogeneity (/2 = 90 %). Prevalence of hallucinations and delusions were lower when measured by NPI scales and in population-based samples.
Discussion:
Delusions and hallucinations occur in MCI patients at low rates. Prevalence can be partially explained by the assessment method, sample source and study heterogeneity.
Insights
Psychotic symptoms like hallucinations and delusions are infrequent in mild cognitive impairment (MCI). Their prevalence is influenced by assessment methods and sample characteristics, highlighting the need for standardized approaches in MCI research.
Area of Science:
- Neurology
- Psychiatry
- Gerontology
Background:
- Neuropsychiatric symptoms can affect prognosis in mild cognitive impairment (MCI).
- Limited data exists on the frequency of psychotic symptoms in MCI patients.
- Understanding these symptoms is crucial for accurate diagnosis and management.
Purpose of the Study:
- To systematically review and estimate the prevalence of hallucinations and delusions in individuals with MCI.
- To explore factors contributing to heterogeneity in reported prevalence rates.
Main Methods:
- Comprehensive literature search of MEDLINE, EMBASE, and PsychoINFO databases up to June 2023.
- Inclusion of 36 studies encompassing 20,426 patients with MCI.
- Application of random effects models for prevalence estimation, with subgroup and meta-regression analyses to address heterogeneity.
Main Results:
- Overall prevalence of hallucinations was 1.78% (95% CI, 1.17-2.71) and delusions was 3.84% (95% CI, 2.71-5.42).
- Significant heterogeneity was observed (I² = 90%).
- Prevalence rates were lower in studies using Neuropsychiatric Inventory (NPI) scales and in population-based samples.
Conclusions:
- Hallucinations and delusions occur at low rates in patients with mild cognitive impairment.
- Assessment methodology and sample source are significant factors influencing reported prevalence.
- Study heterogeneity can be partially explained by these methodological variations.
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