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Cannabidiol and pain.
Glauce Crivelaro Nascimento1, Daniela Escobar-Espinal1, Gabriela Gonçalves Bálico1
1Department of Basic and Oral Biology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
International Review of Neurobiology
|July 19, 2024
Summary
Cannabidiol (CBD) shows promise for chronic pain relief, offering a safer alternative to inadequate traditional treatments. Further research is needed to understand its full potential and mechanisms for managing various pain types.
Area of Science:
- Pharmacology
- Pain Management
- Neuroscience
Background:
- Chronic pain affects over 30% of adults globally, causing significant disability.
- Current pharmacotherapies offer relief to less than 70% of patients, highlighting a need for alternatives.
- Cannabidiol (CBD), a cannabinoid, is being explored for its potential pain-relieving properties and safety profile.
Purpose of the Study:
- To explore the therapeutic potential of cannabidiol (CBD) in managing chronic pain.
- To review existing evidence on CBD's efficacy and safety as an alternative pain management strategy.
- To understand the mechanisms by which CBD may exert analgesic effects.
Main Methods:
- Review of preclinical (animal) studies on CBD's analgesic effects.
- Analysis of existing literature on cannabinoid use in pain management.
- Examination of CBD's interaction with the endocannabinoid, inflammatory, and nociceptive systems.
Main Results:
- Animal studies suggest CBD possesses pain-relieving properties.
- CBD may offer a safer alternative with a reduced risk of addiction compared to traditional analgesics.
- Evidence indicates potential benefits for cancer-related, neuropathic, arthritis, and musculoskeletal pain.
Conclusions:
- Cannabidiol (CBD) presents a promising avenue for chronic pain management, particularly where conventional treatments are insufficient.
- While promising, the efficacy and optimal use of CBD for pain require further rigorous investigation.
- Understanding CBD's role in modulating key physiological systems is crucial for its clinical application in pain relief.
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