Related Experiment Video
Updated: May 6, 2026

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
Transcatheter vs. surgical mitral valve interventions in patients with prior coronary artery bypass grafting
Mahmoud Ismayl1, Hasaan Ahmed2, Andrew M Goldsweig3
1Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Insights
Transcatheter mitral valve interventions are increasingly used in patients with prior coronary artery bypass grafting, showing similar mortality and readmission rates compared to surgical methods.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Cardiac Surgery
Background:
- Many patients needing mitral valve (MV) intervention have a history of coronary artery bypass grafting (CABG).
- Reoperative cardiac surgery carries elevated risks.
Purpose of the Study:
- To compare the utilization and outcomes of transcatheter versus surgical MV interventions in patients with prior CABG.
- To assess the safety and efficacy of minimally invasive approaches in this high-risk population.
Main Methods:
- Analysis of the Nationwide Readmission Database (2016-2021).
- Inclusion of adult patients with prior CABG undergoing transcatheter or surgical MV intervention.
- Comparison of in-hospital outcomes and readmissions using multivariable regression, propensity-matching, and Cox proportional hazards models.
Main Results:
- Transcatheter MV interventions increased significantly among patients with prior CABG from 2016-2021.
- Similar in-hospital mortality and 180-day heart failure readmissions were observed for transcatheter versus surgical MV interventions.
- Transcatheter approaches were associated with lower rates of stroke, acute kidney injury, permanent pacemaker placement, shorter length of stay, and fewer non-home discharges, but higher vascular complications with replacement.
Conclusions:
- Transcatheter MV interventions are becoming the preferred choice for patients with prior CABG.
- These procedures demonstrate comparable safety and effectiveness to surgical interventions regarding mortality and heart failure readmissions.
Background:
A significant proportion of patients requiring mitral valve (MV) intervention have undergone prior coronary artery bypass grafting (CABG). Reoperative heart surgery is associated with increased risk.
Aims:
To evaluate the utilization and outcomes of transcatheter vs. surgical MV interventions in patients with prior CABG.
Methods:
We queried the Nationwide Readmission Database (2016-21) to identify adults with prior CABG hospitalized for transcatheter or surgical MV intervention. In-hospital outcomes were compared using multivariable regression and propensity-matching analyses. Readmissions were compared using Cox proportional hazards regression model.
Results:
Of 305 625 weighted hospitalizations for MV intervention, 23 506 (7.7%) occurred in patients with prior CABG. From 2016Q1-2021Q4, the use of transcatheter MV interventions increased among patients with prior CABG (72 to 191 for repair and 6 to 45 for replacement per 100 000 hospitalizations, both ptrend < 0.001). Compared with surgical MV repair and replacement, transcatheter MV repair and replacement were associated with similar in-hospital mortality (adjusted odds ratio [aOR] 0.44, 95% confidence interval [CI] 0.20-1.03 for repair; aOR 0.61, 95% CI 0.38-1.02 for replacement) and 180-day heart failure (HF) readmissions (adjusted hazard ratio [aHR] 1.56, 95% CI 0.85-2.87 for repair; aHR 1.15, 95% CI 0.63-2.09 for replacement) and lower stroke, acute kidney injury, permanent pacemaker placement, length of stay, and non-home discharges, respectively. Vascular complications were higher with transcatheter vs. surgical MV replacement.
Conclusion:
Transcatheter MV interventions are increasingly used as the preferred modality of MV intervention in patients with prior CABG and are associated with similar in-hospital mortality and 180-day HF readmissions compared with surgical MV interventions.
Related Concept Videos
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation III: Medical Management
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management
Mitral Stenosis IV: Nursing Management
Aortic Regurgitation III: Medical Management

