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Genomic Reference Resource for African Cattle: Genome Sequences and High-Density Array Variants.

Abdulfatai Tijjani^1,2, Sumaya Kambal^3,4, Endashaw Terefe⁵

¹Centre for Tropical Livestock Genetics and Health (CTLGH), ILRI Ethiopia, P.O. Box 5689, Addis Ababa, Ethiopia. abdulfatai.tijjani@gmail.com.

Scientific Data

|July 19, 2024

Summary

New genomic data from 555 African cattle, including 208 new genome sequences, enhances breed improvement and resilience research. This resource aids in characterizing indigenous breeds and advancing global livestock genetics.

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Area of Science:

Genomics
Animal Science
Bioinformatics

Background:

Genomic diversity is crucial for improving local cattle breeds and understanding resilience mechanisms.
Existing genome resources for African cattle are limited, hindering comprehensive characterization and utilization.

Purpose of the Study:

To generate and present new genome sequences and high-density genotyping data for indigenous African cattle.
To expand the genomic reference resource for African cattle (GRRFAC) for breed characterization and sustainable livestock improvement.

Main Methods:

Sequencing of 555 cattle genomes (208 new) with average ~30X coverage.
High-density (HD) array genotyping of 1,082 cattle samples (537 new).
Variant calling and mapping to the Bos taurus reference genome (ARS-UCD1.2).

Main Results:

Identification of approximately 32.3 million sequence variants.
Discovery of 661,943 HD autosomal variants.
Generation of significantly higher coverage genome data compared to public domain resources.

Conclusions:

The new genomic datasets significantly enrich the resource for African cattle.
This initiative supports comprehensive indigenous breed characterization and sustainable global livestock improvement.
Enhanced genomic resources facilitate gene discovery and understanding of cattle resilience.