Higher processing repeatability of myocardial flow reserve calculated using net retention model compared to one...

Area of Science:

• Nuclear Cardiology
• Cardiovascular Imaging
• Medical Physics

Background:

• Dynamic assessment of myocardial blood flow (MBF) and myocardial flow reserve (MFR) enhances diagnostic accuracy in myocardial perfusion imaging.
• Previous studies highlighted variability in processing repeatability for these parameters.

Purpose of the Study:

• To assess the processing repeatability of MBF and MFR calculated using the net retention (RET) and one compartment (1CM) models.
• To evaluate the impact of the latest Corridor 4DM software (v2024) on processing repeatability compared to v2015.

Main Methods:

• Retrospective analysis of dynamic SPECT studies from 107 patients using Corridor 4DM v2024.
• Data processed twice by one operator and once by another to assess interobserver repeatability.
• Comparison of processing repeatability between RET and 1CM models.

Main Results:

• Corridor 4DM v2024 significantly improved automatic heart image positioning, reducing manual corrections from 41% to 12%.
• Interobserver repeatability for MFR in the RCA territory improved from r=0.67 to r=0.85 (p=0.0034) compared to v2015.
• The RET model demonstrated significantly better interobserver processing repeatability for both MBF and MFR compared to the 1CM model.

Conclusions:

• The net retention (RET) model is more reliable for calculating MBF and MFR from dynamic SPECT studies.
• The latest Corridor 4DM software (v2024) offers improved processing repeatability, enhancing the clinical utility of dynamic myocardial perfusion imaging.