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Inflammatory bowel disease and risk for hemorrhoids: a Mendelian randomization analysis
HanYu Wang1, Lu Wang1, XiaoYu Zeng1
1Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Scientific Reports
|July 19, 2024
Summary
This study found a causal link between Crohn's disease (CD) and hemorrhoids (HEM). These findings suggest that preventing hemorrhoids in CD patients is crucial for clinical management.
Area of Science:
- Gastroenterology
- Genetics
- Epidemiology
Background:
- Observational studies suggest an association between inflammatory bowel disease (IBD) and hemorrhoids (HEM).
- The causal relationship between IBD and HEM requires further investigation.
- Mendelian randomization (MR) is a robust method for inferring causality from observational data.
Purpose of the Study:
- To investigate the causal effect of IBD, including Crohn's disease (CD) and ulcerative colitis (UC), on hemorrhoids (HEM).
- To validate the association between IBD and HEM using genome-wide association studies (GWAS) data.
- To provide evidence-based recommendations for clinical practice regarding IBD and HEM management.
Main Methods:
- A two-sample Mendelian randomization (MR) study was conducted using GWAS data from European populations.
- Genetic variants associated with IBD (overall, CD, and UC) and HEM were identified.
- Multivariable Mendelian randomization (MVMR) was employed to adjust for potential confounders.
Main Results:
- Genetically predicted overall IBD showed a positive association with HEM risk in both training and validation sets.
- Crohn's disease (CD) was significantly associated with an increased risk of hemorrhoids (HEM).
- Ulcerative colitis (UC) showed a positive association with HEM in the training set, but this was not significant in the validation set or after MVMR adjustment.
Conclusions:
- There is a causal relationship between Crohn's disease (CD) and hemorrhoids (HEM).
- Clinicians should consider the increased risk of hemorrhoids in patients with Crohn's disease.
- Further research may explore the underlying mechanisms linking CD and HEM.
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