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Biomarkers in Cutaneous Keratinocyte Carcinomas
Erica Montano1, Neal Bhatia2, Jelena Ostojić3
1DermTech, Inc., 12340 El Camino Real, San Diego, CA, 92130, USA.
Dermatology and Therapy
|July 19, 2024
Summary
This review covers biomarkers for basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC), focusing on molecular and histologic markers for patient management, including diagnosis and therapy selection.
Area of Science:
- Oncology
- Dermatology
- Biomarker Research
Background:
- Skin cancer is the most common cancer in the USA, with non-melanoma skin cancers (NMSC) like basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) on the rise.
- BCC and SCC present significant morbidity, including disfigurement and chronic pain, leading to high healthcare costs.
- Diverse clinical presentations of BCC and SCC necessitate the development of specific biomarkers for accurate diagnosis and patient management.
Purpose of the Study:
- To review known and emerging molecular and histologic biomarkers for BCC and SCC.
- To highlight the relevance of these biomarkers in patient management, encompassing prevention, risk assessment, diagnosis, and therapy selection.
Main Methods:
- Comprehensive literature review of scientific publications.
- Focus on molecular and histologic biomarkers.
- Analysis of biomarker relevance for clinical applications.
Main Results:
- Identified key molecular and histologic biomarkers for BCC and SCC.
- Discussed the role of biomarkers in risk stratification and early detection.
- Highlighted biomarkers influencing treatment decisions and therapeutic strategies.
Conclusions:
- Biomarker profiling is crucial for advancing the understanding and management of BCC and SCC.
- Emerging biomarkers offer potential for improved diagnostic accuracy and personalized treatment selection.
- Further research into skin biomarkers is essential for better patient outcomes in NMSC.
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