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Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Myeloid-derived growth factor in diseases: structure, function and mechanisms.

Peng Chen1,2, Xiaohui Huang1,2, Weiwen Li1,2

  • 1Department of Cardiology, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde, NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan City, Guangdong, 528308, China.

Molecular Medicine (Cambridge, Mass.)
|July 19, 2024
PubMed
Summary

Myeloid-derived growth factor (MYDGF) is a novel protein promoting tissue repair and preventing cell death. This review explores MYDGF

Keywords:
Autoimmune/inflammatory disordersCancersCardiovascular diseasesMetabolic disordersMyeloid-derived growth factorRenal disease

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Myeloid-derived growth factor (MYDGF) is a secreted protein found in numerous human tissues.
  • Initially identified for its role in cardioprotection post-myocardial infarction, its functions extend to various diseases.
  • MYDGF exhibits potent antiapoptotic and tissue-repairing properties.

Purpose of the Study:

  • To review the current understanding of MYDGF's role in health and disease.
  • To focus on MYDGF's structure, function, and underlying mechanisms.
  • To highlight MYDGF's involvement in diverse physiological and pathological processes.

Main Methods:

  • Literature review of existing studies on MYDGF.
  • Synthesis of data regarding MYDGF's presence in tissues and cell lines.
  • Analysis of reported functions and proposed mechanisms of action.

Main Results:

  • MYDGF is abundant in oral epithelium and skin, with presence in nearly 140 human tissues.
  • MYDGF is implicated in cardiovascular diseases, metabolic disorders, renal disease, inflammatory conditions, and cancers.
  • Potential mechanisms involve regulation of apoptosis, proliferation, tissue repair, and glycolipid metabolism.

Conclusions:

  • MYDGF is a significant factor in maintaining tissue homeostasis and responding to injury.
  • Further research is needed to fully elucidate the complex mechanisms of MYDGF.
  • MYDGF represents a potential therapeutic target for a wide range of diseases.