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Growth in healthy infants with cow's milk protein allergy fed extensively hydrolyzed or amino acid-based formulas

Armen Malekiantaghi1, Mahbobeh Aghajani2, Hosein Shabani-Mirzaee3

  • 1Department of Pediatric Gastroenterology, Bahrami Children's Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

BMC Nutrition
|July 19, 2024
PubMed

Insights

Infants with cow's milk protein allergy (CMPA) fed extensively hydrolyzed formulas (EHFs) showed better growth than those on amino acid-based formulas (AAFs). Both formula types supported age-appropriate growth, but EHFs led to higher growth parameters.

Area of Science:

  • Pediatric Nutrition
  • Allergy and Immunology
  • Growth and Development

Background:

  • Cow's milk protein allergy (CMPA) is a prevalent condition in infants.
  • Specialized infant formulas, including extensively hydrolyzed formulas (EHFs) and amino acid-based formulas (AAFs), are used for CMPA management.
  • Evaluating growth outcomes in infants with CMPA is crucial for assessing nutritional adequacy.

Purpose of the Study:

  • To compare the growth of infants diagnosed with CMPA and fed either EHFs or AAFs.
  • To assess the suitability of growth criteria in infants with CMPA on specialized formulas against WHO growth charts.

Main Methods:

  • A prospective chart review was conducted on infants with CMPA.
  • Infants were divided into two groups: one receiving EHFs and the other AAFs.
  • Growth parameters (weight, length, head circumference) were evaluated until one year of age.

Main Results:

  • Fifty-eight infants were included in the study.
  • While both formula groups exhibited age-appropriate growth, infants fed EHFs demonstrated higher growth parameters compared to those on AAFs.
  • Earlier diagnosis and treatment were observed in the AAFs group.

Conclusions:

  • Both EHFs and AAFs support suitable growth in infants with CMPA, aligning with WHO growth standards.
  • Extensively hydrolyzed formulas may promote a higher growth rate in infants with CMPA compared to amino acid-based formulas.
Abstract

Keywords:
Allergy to cow’s milk proteinAmino acid-based formulaExtensively hydrolyzed formulaGrowthInfant

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