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Oral Biofilm Formation on Different Materials for Dental Implants

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Published on: June 24, 2018

Antimicrobial Potential of Strontium-Functionalized Titanium Against Bacteria Associated With Peri-Implantitis.

Hatem Alshammari^1,2, Jessica Neilands³, Christian Sloth Jeppesen⁴

¹Department of Preventive Dentistry, College of Dentistry, University of Hail, Hail, Saudi Arabia.

Clinical and Experimental Dental Research

|July 20, 2024

Summary

Strontium-functionalized wafers show significant antimicrobial effects against bacteria causing peri-implant infections. These wafers reduce viable bacterial cells and inhibit key enzymes in both single and mixed bacterial biofilms.

Keywords:

antimicrobial coatings dental implant peri‐implantitis strontium titanium

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Area of Science:

Biomaterials Science
Microbiology
Dental Implantology

Background:

Peri-implant infections pose a significant threat to dental implant success.
Developing effective antimicrobial strategies for implant surfaces is crucial.
Current treatments often struggle with biofilm eradication.

Purpose of the Study:

To evaluate the antimicrobial efficacy of strontium (Sr)-functionalized wafers against bacteria linked to peri-implant infections.
To assess the impact of Sr functionalization on mono- and multispecies biofilms.
To investigate the effect on specific bacterial virulence factors like gingipain.

Main Methods:

Silicon wafers coated with strontium titanium oxygen (Sr-Ti-O) or titanium (Ti) were tested.
Bacterial viability and colony-forming units (CFUs) were measured in mono- and multispecies biofilms.
Quantitative PCR (qPCR) and gingipain activity assays were used to assess specific bacterial presence and virulence.

Main Results:

Sr-functionalized wafers significantly reduced viable bacterial cells compared to controls in both mono- and multispecies biofilms.
A significant decrease in CFUs was observed for Staphylococcus aureus and Escherichia coli on Sr-functionalized wafers.
Sr functionalization reduced gingipain activity and kept Porphyromonas gingivalis below detection levels in multispecies biofilms.

Conclusions:

Strontium functionalization demonstrates potent antimicrobial and antibiofilm properties.
Sr-functionalized materials offer a promising approach for preventing and treating peri-implant infections.
This technology could enhance the longevity and success of dental implants.