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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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  11. Effect Of Multimodal Intervention In Individuals With Mild Cognitive Impairment: A Randomized Clinical Trial In Shanghai

Effect of Multimodal Intervention in Individuals with Mild Cognitive Impairment: A Randomized Clinical Trial in Shanghai

Meixiang Fan1,2, Qingfeng Li3, Tingting Yang4

  • 1Department of General Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Journal of Alzheimer'S Disease : JAD
|July 20, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Multimodal training significantly improved cognitive function in individuals with mild cognitive impairment (MCI). This intervention enhanced cognitive performance and brain connectivity, offering a promising approach for MCI management.

Area of Science:

  • Neurology
  • Cognitive Science
Keywords:
Alzheimer’s diseasebehavior therapyclinical trialcognitive dysfunction

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  • Neuroimaging

    • Background:

    • Previous studies suggest multimodal training benefits cognitive functions and mood in mild cognitive impairment (MCI).
    • Evidence primarily comes from high-income countries, necessitating research in diverse settings.

    Purpose of the Study:

    • To evaluate the efficacy, safety, and underlying mechanisms of a multimodal intervention for cognitive function in community-dwelling individuals with MCI.
    • To provide evidence for multimodal interventions in non-high-income settings.

    Main Methods:

    • A single-blind, randomized controlled trial involving 120 participants diagnosed with MCI.
    • Participants were allocated to either a multimodal intervention group or a control group receiving standard health education.
    • Cognitive assessments (e.g., MMSE, AVLT, DSST) and MRI scans were performed at baseline and after a 12-week intervention period.

    Main Results:

    • The intervention group demonstrated significant improvements in overall cognitive scores (MMSE) and specific domains including recall, language, immediate memory, processing speed, and digit span.
    • Neuroimaging revealed enhanced structural and functional connectivity in brain regions associated with language, attention, executive function, memory, and recall in the intervention group.
    • The intervention was found to be safe and effective in improving cognitive performance and neurobiological markers in individuals with MCI.

    Conclusions:

    • Multimodal intervention effectively enhances cognitive performance in individuals with mild cognitive impairment.
    • The intervention also leads to measurable improvements in brain structure and function, as evidenced by neuroimaging.
    • This study supports the use of multimodal training as a viable strategy for managing MCI, with potential benefits observed in cognitive and neural measures.