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Omalizumab for management of hypersensitivity reactions to anticancer drugs
Piyush Grover1,2,3, Matthew Krummenacher1, Timothy Loy1
1Department of Immunology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Abstract:
Hypersensitivity reactions to anticancer drugs include treatment-limiting toxicity. Standard drug desensitisation offers temporary tolerance and hence requires repetition. We used omalizumab, an anti-immunoglobulin E antibody, to overcome immediate and delayed hypersensitivity reactions to various anticancer drugs. Seven of the eight patients in the current study successfully resumed the desired anticancer drug regimen without standard desensitisation. No safety issues from omalizumab were observed.
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