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Updated: Jun 20, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Modular and Photoreversible Polymer-Nanoparticle Hydrogels via Host-Guest Interactions.

Stéphane Bernhard1, Lauritz Ritter1, Marco Müller1

  • 1Macromolecular Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, 8092, Switzerland.

Small (Weinheim an Der Bergstrasse, Germany)
|July 20, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces tunable polymer-nanoparticle hydrogels using beta-cyclodextrin host-guest interactions for improved biomedical applications. The research explores how these interactions influence network formation and enables light-responsive gelation.

Keywords:
host–guest chemistryinjectable hydrogelsnanoparticlesself‐assemblysupramolecular materials

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Polymer-nanoparticle (PNP) hydrogels are promising injectable biomaterials.
  • Current PNP hydrogel design is limited by poor understanding of binding motif effects on viscoelastic properties and non-responsive interactions.
  • Expanding interaction types and understanding their influence on network formation is crucial for advancing PNP hydrogel design.

Purpose of the Study:

  • To design and investigate a tunable PNP hydrogel platform utilizing beta-cyclodextrin (βCD) host-guest cross-links.
  • To understand how host-guest interactions influence PNP hydrogel network formation and properties.
  • To engineer photoreversible PNP hydrogels using photo-responsive guests.

Main Methods:

  • Synthesis of a host-functionalized polymer (βCD hyaluronic acid) and guest-bearing nanoparticles (poly(ethylene glycol)-b-poly(lactic acid)).
  • Characterization of host and guest moiety binding using isothermal titration calorimetry.
  • Fabrication and analysis of PNP hydrogels with varying component concentrations and incorporation of photo-responsive guests.

Main Results:

  • Successful synthesis of functionalized polymers and nanoparticles for βCD host-guest cross-linking.
  • Identification of a specific concentration window required for PNP hydrogel gelation.
  • Demonstration of photoreversible gelation in PNP hydrogels upon light exposure.

Conclusions:

  • The study presents a novel, tunable PNP hydrogel platform based on βCD host-guest chemistry.
  • Hydrogel network formation is significantly influenced by host-guest ratios and polymer chain bridging capacity.
  • The incorporation of photo-responsive guests enables the development of light-controllable injectable hydrogels for biomedical applications.