Malpresentation and autism spectrum disorder in the study to explore early development.
Yitian Zhang1,2, Michelle T Delahanty2, Stephanie M Engel2
1Epidemiology and Database Studies, Real World Solutions, IQVIA Inc, Durham, USA.
Paediatric and Perinatal Epidemiology
|July 20, 2024
Summary
Infants with non-vertex presentation (malpresentation) at birth had higher odds of autism spectrum disorder (ASD). Early monitoring of these children may improve developmental support and outcomes.
Area of Science:
- Neonatal development
- Neurodevelopmental disorders
- Obstetrics
Background:
- Infant presentation at birth can indicate developmental differences.
- Non-vertex presentation (malpresentation) is linked to complications and neurodevelopmental delays, including autism spectrum disorder (ASD).
- Limited research exists on the malpresentation-ASD association.
Purpose of the Study:
- To investigate the association between malpresentation at delivery and ASD.
- To determine if gestational age modifies this association.
Main Methods:
- Utilized data from the Study to Explore Early Development (SEED), a multi-site case-control study.
- Defined malpresentation as non-vertex presentation, categorizing into breech and other types.
- Employed multivariable logistic regression to analyze the association between malpresentation and ASD.
Main Results:
- Included 4047 participants (1873 with ASD, 2174 controls).
- Malpresentation was associated with increased odds of ASD (aOR 1.31, 95% CI 1.02-1.68), adjusted for confounders.
- The association was consistent across malpresentation types and gestational ages.
Conclusions:
- Malpresentation at delivery shows a modest association with ASD.
- Suggests early neurodevelopmental monitoring for infants with malpresentation to facilitate timely ASD identification and support.
- Optimizing developmental outcomes for children with ASD through early intervention.
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