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Accessory Structures of the Eye

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Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...

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Updated: Jun 20, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Lymph Node Evolution in Eyelid and Orbit Squamous Cell Carcinomas.

Emilien Chebib¹, Guillaume Rougier¹, Antoine Dubray-Vautrin¹

¹Head & Neck Oncologic and Reconstructive Surgery Department, Institut Curie, Ear, Nose & Throat, Paris, France.

The Laryngoscope

|July 20, 2024

Summary

This summary is machine-generated.

Squamous cell carcinomas (SCCs) of the eyelid and periorbital region can spread to lymph nodes, particularly the parotid gland. Tumor size, invasion, and recurrence increase this risk, necessitating careful evaluation and potential dissection.

Keywords:

eyelid lymph nodes orbit parotid gland squamous cell carcinomas

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

Ophthalmology
Dermatology
Head and Neck Surgery

Background:

Squamous cell carcinoma (SCC) of the eyelid and periorbital region is a common skin malignancy.
Understanding the patterns and risk factors for lymph node metastasis is crucial for effective management.

Purpose of the Study:

To characterize a large cohort of eyelid and periorbital SCCs.
To compare tumor location with pathological lymph node sites.
To identify risk factors associated with lymph node involvement.

Main Methods:

Retrospective analysis of patients with eyelid and periorbital SCCs.
Evaluation of tumor characteristics, imaging, excision margins, and lymph node status.
Univariate and multivariate analyses to determine risk factors for lymph node involvement.

Main Results:

15.7% of patients (18/115) developed lymph node metastasis.
Parotid gland involvement was most common (88.9%), followed by submental/submandibular (38%) and jugular/carotid areas (22%).
Risk factors for lymph node metastasis included tumor size >20mm, invasion of canthus/periorbital structures, perineural/vascular invasion, deep infiltration, and local recurrence.

Conclusions:

Periorbital and eyelid SCCs have a significant potential for lymph node metastasis, primarily via the parotid gland.
Mandatory inclusion of parotid gland and neck in imaging and assessment is recommended.
Lymph node dissection should be considered in cases of parotidectomy for confirmed lymph node involvement.