Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alteration of individual morphological brain networks in preschool children with autism spectrum disorder.

Brain imaging and behavior·2026
Same author

Layered Copper-Anthraquinone Coordination Polymer Cathode Leveraging Dual-Redox Sites and Facilitated Ion Diffusion for High-Performance Lithium-Ion Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Altered static and dynamic functional network connectivity in Parkinson's disease: A multisite functional magnetic resonance imaging study.

IBRO neuroscience reports·2026
Same author

The effectiveness of a plant-based milk with fermented brown rice on constipation symptoms via gut microbiota modulation: a double-blind randomized controlled trial.

European journal of nutrition·2026
Same author

Self-Adaptive AdamW-Guided Optimization: A Learning-Driven Metaheuristic for Solving Complex Real-World Engineering Problems.

Entropy (Basel, Switzerland)·2026
Same author

Liver transplantation promotes early neural reorganization in minimal hepatic encephalopathy: a longitudinal resting state fMRI study.

Metabolic brain disease·2026
Same journal

A computer-aided diagnosis tool in prostate cancer patients with biochemical recurrence using 18F-PSMA PET/CT imaging.

Medical physics·2026
Same journal

Investigating the uncertainty of cellular microenvironment parameter estimations via diffusion MRI cytometry.

Medical physics·2026
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K

Biological-equivalent-dose-based integrated optimization framework for fast-energy-switching Bragg peak FLASH-RT

Yiling Zeng1,2,3, Heng Li4, Qi Zhang1

  • 1Department of Medical Physics, School of Physics and Technology, Wuhan University, Wuhan, China.

Medical Physics
|July 20, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces an integrated optimization framework for FLASH radiotherapy, improving normal tissue sparing with single beam per fraction schedules. The developed framework effectively compensates for potential dose increases, enhancing treatment safety.

Keywords:
Bragg peak proton therapyFLASH effectequivalent dose in 2 Gysingle beam per fraction

More Related Videos

Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation
12:29

Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation

Published on: March 20, 2018

9.4K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.8K

Related Experiment Videos

Last Updated: Jun 20, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K
Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation
12:29

Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation

Published on: March 20, 2018

9.4K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.8K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Optimization

Background:

  • Single beam per fraction (SBPF) schedules in FLASH radiotherapy meet dose thresholds and reduce beam switching uncertainties.
  • SBPF may increase the biological equivalent dose in 2 Gy (EQD2) for normal tissues, posing a challenge for sparing.
  • Optimizing FLASH plans requires balancing dose delivery, efficiency, and normal tissue protection.

Purpose of the Study:

  • To develop an EQD2-based integrated optimization framework (EQD2-IOF) for Bragg peak FLASH plans using SBPF.
  • To incorporate robust dose, delivery efficiency, and beam orientation optimization (BOO) into the EQD2-IOF.
  • To enhance both normal tissue sparing and the FLASH effect in radiotherapy.

Main Methods:

  • Utilized a superconducting gantry with fast energy switching (27 ms) and universal range shifters for FLASH plans.
  • Implemented a simultaneous dose and spot map optimization (SDSMO) algorithm within a Bayesian optimization auto-planning framework.
  • Developed a BOO algorithm using Tabu search for beam angle combination selection and a quantitative model for FLASH-enhanced dose distribution.

Main Results:

  • EQD2-IOF plans showed no significant difference in target dose coverage (D2% and D98%) compared to manually optimized plans.
  • EQD2-IOF plans achieved a significant reduction in mean EQD2 for the ipsilateral lung (10.5%) and normal tissue (11.5%) compared to manual plans.
  • FLASH sparing in normal tissues receiving >70% of the prescription dose compensated for increased EQD2 when using SBPF schedules.

Conclusions:

  • The EQD2-IOF automates SBPF FLASH-RT plan optimization for superior normal tissue sparing.
  • The FLASH effect can compensate for potential fractionation repair loss in high-dose regions with fast (27 ms) energy switching.
  • SBPF schedules require careful consideration with slower energy switching (500 ms) due to diminished FLASH effect.