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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

1.9K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
1.9K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Pleiotropy01:33

Pleiotropy

40.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.4K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.2K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Relationship Between Psoriasis And Vitiligo: From A Comprehensive Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Relationship Between Psoriasis And Vitiligo: From A Comprehensive Study.

Related Experiment Video

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.9K

The relationship between psoriasis and vitiligo: From a comprehensive study.

Junchen Li1, Qian Shen2, Yingdong Wang1

  • 1Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|July 20, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study found no causal link between psoriasis and vitiligo, despite both being autoimmune skin diseases. While immune cells are involved, genetic analysis suggests the conditions do not cause each other.

Keywords:
Mendelian randomizationcausationcorrelationpsoriasis

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

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Related Experiment Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.9K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

374
Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.5K

Area of Science:

  • Immunodermatology
  • Genetics
  • Autoimmune Diseases

Background:

  • Psoriasis and vitiligo are autoimmune skin conditions with observed associations.
  • Simultaneous onset increases patient health risks.
  • Causal links between psoriasis and vitiligo remain under-researched.

Purpose of the Study:

  • To investigate a potential causal association between psoriasis and vitiligo.

Main Methods:

  • Case report with transcriptome and single-cell transcriptome sequencing of skin tissues.
  • Mendelian randomization analysis using Genome-wide association studies (GWAS) data from European cohorts.

Main Results:

  • Transcriptome analysis revealed immune cell changes in co-morbid skin.
vitiligo
  • Mendelian randomization showed no significant causal relationship in either direction between psoriasis and vitiligo.
  • Forward direction: p=0.192, OR=1.059. Reverse direction: p=0.459, OR=0.927.

    • Conclusions:

    • The association between psoriasis and vitiligo appears linked to immune system activity.
    • Mendelian randomization does not support a causal relationship.
    • Findings aid clinicians in understanding and managing these autoimmune skin diseases.