Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving the PLASMIC score with the use of RDW-SD in the differential diagnosis for thrombotic thrombocytopenic purpura in Chinese patients.

Annals of clinical biochemistry·2025

Same author

Developing a Prognostic Model for Predicting the Risk of Outcome in Patients With Novel Bunyavirus Infection: A Retrospective Study.

Journal of medical virology·2025

Same author

The mismatch between Sysmex XN-20 automated hematology analyzers and the visual examination of blood smears-Misclassification of hypogranular eosinophils and platelets.

International journal of laboratory hematology·2023

Same author

A case of neutrophil blue-green inclusions in severe fever with thrombocytopenia syndrome virus infection.

International journal of laboratory hematology·2023

Same author

Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2021

Same author

Increased expression of TAZ and associated upregulation of PD-L1 in cervical cancer.

Cancer cell international·2021

Search research articles

Related Experiment Video

Updated: Apr 30, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

Evaluation of artificial intelligence-assisted morphological analysis for platelet count estimation.

Ping Guo¹, Chi Zhang², Dandan Liu³

¹Clinical Laboratory, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International Journal of Laboratory Hematology

|July 20, 2024

Summary

Artificial intelligence on the MC-80 digital morphology analyzer accurately estimates platelet counts. This AI technology improves accuracy for platelet transfusion decisions, especially in low platelet count samples.

Keywords:

artificial intelligence digital morphology analyzer method comparison platelet count estimation

More Related Videos

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Apr 30, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Area of Science:

Hematology
Medical technology
Artificial intelligence in diagnostics

Background:

Platelet count estimation is crucial for diagnosing and managing various medical conditions.
Current methods may have limitations in accuracy, particularly with abnormal samples.

Purpose of the Study:

To evaluate the performance of platelet count estimation using artificial intelligence (AI) on the MC-80 digital morphology analyzer.
To compare AI-based estimations with traditional methods and flow cytometry.

Main Methods:

The MC-80 analyzer utilizes two AI principles for platelet count estimation: PLT/RBC ratio (PLT-M1) and estimate factor (PLT-M2).
977 samples with varying platelet counts were analyzed, with 271 subjected to immunoassay.
Platelet counts from the MC-80 analyzer were compared against a hematology analyzer (PLT-I, PLT-O) and flow cytometry (PLT-IRM).

Main Results:

Both PLT-M1 and PLT-M2 showed minimal deviation and strong correlation with flow cytometry (PLT-IRM), outperforming standard hematology counts (PLT-I).
AI estimations demonstrated robust correlation even with interfering factors like large platelets or RBC fragments.
The AI methods provided higher accuracy for platelet transfusion decisions, particularly for samples with low platelet values.

Conclusions:

The MC-80 digital morphology analyzer's AI-driven platelet count estimation offers high accuracy.
The reviewed AI results effectively confirm suspicious platelet counts, enhancing diagnostic confidence.