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Updated: Jun 20, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Published on: September 20, 2016

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Molecular insights into the role of mixed lineage kinase 3 in cancer hallmarks

Rong Ke1, Sandeep Kumar2, Sunil Kumar Singh3

  • 1Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.

Biochimica Et Biophysica Acta. Reviews on Cancer
|July 20, 2024
PubMed

Insights

Mixed-lineage kinase 3 (MLK3) is a key regulator in cancer, influencing cell processes and hallmarks. Understanding MLK3

Area of Science:

  • Oncology
  • Molecular Biology
  • Signal Transduction

Background:

  • Mixed-lineage kinase 3 (MLK3), a MAP3K family member, is implicated in diverse biological processes.
  • MLK3 activation influences canonical MAPK pathways (JNK, p38, ERK) and non-canonical pathways (β-catenin, AMPK, Pin1, PAK1).
  • Emerging roles of MLK3 in malignancy include metabolic reprogramming, inflammation, and immune evasion.

Purpose of the Study:

  • To review the multifaceted roles of MLK3 in cancer.
  • To elucidate MLK3's impact on the established hallmarks of cancer.
  • To highlight MLK3 as a potential therapeutic target for MLK3-dependent cancers.

Main Methods:

  • Literature review of studies on MLK3 function in cancer.
  • Analysis of MLK3's involvement in cell proliferation, apoptosis, invasion, and metastasis.
  • Examination of MLK3's contribution to metabolic reprogramming, inflammation, and immune surveillance in cancer.

Main Results:

  • MLK3 regulates key cellular processes critical for cancer progression.
  • MLK3 influences multiple cancer hallmarks, including sustained proliferative signaling, evading growth suppressors, resisting cell death, and enabling replicative immortality.
  • MLK3's complex and cancer-specific roles necessitate detailed molecular understanding.

Conclusions:

  • MLK3 plays a significant, context-dependent role in cancer development and progression.
  • Targeting MLK3 offers potential therapeutic strategies for specific cancer types.
  • Further research into MLK3's molecular mechanisms is crucial for developing effective anticancer therapies.
Keywords:
Cancer hallmarksCancer-associated inflammationEvasion of immune surveillanceMLK3Metabolic reprogramming

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