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Risks of developing major psychiatric disorders among child and adolescent intensive care unit survivors

Ping-Chung Wu1, Shih-Jen Tsai2, Ya-Mei Bai2

  • 1Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.

Journal of Affective Disorders
|July 20, 2024
PubMed

Insights

Child and adolescent intensive care unit (ICU) survivors face higher risks for major psychiatric disorders (MPDs), including PTSD and schizophrenia. This highlights the need for targeted MPD prevention strategies for these vulnerable young patients.

Area of Science:

  • Pediatric critical care medicine
  • Child and adolescent psychiatry
  • Public health research

Background:

  • Child and adolescent mental health post-intensive care unit (ICU) admission is under-researched.
  • Limited data exists on how critical illness types impact specific psychiatric disorders in pediatric populations.

Purpose of the Study:

  • To investigate the association between pediatric ICU survival and the risk of developing five major psychiatric disorders (MPDs).
  • To quantify the risks of schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), obsessive compulsive disorder (OCD), and posttraumatic stress disorder (PTSD) in pediatric ICU survivors.

Main Methods:

  • Analysis of a nationwide dataset including 8,704 pediatric ICU survivors and 87,040 matched controls from 1996-2013.
  • Longitudinal follow-up to assess the incidence of five MPDs.

Main Results:

  • Pediatric ICU survivors showed significantly elevated risks for all five MPDs compared to controls.
  • Specific hazard ratios (HRs) included: PTSD (HR=4.67), schizophrenia (HR=3.19), BD (HR=2.02), OCD (HR=1.96), and MDD (HR=1.68).
  • The risk of MPDs varied depending on the type of critical illness leading to ICU admission.

Conclusions:

  • Pediatric ICU survivors have a substantially higher risk of developing major psychiatric disorders.
  • Emphasizing MPD prevention strategies is crucial for this high-risk pediatric population.
Abstract

Keywords:
Critical illnessMajor psychiatric disordersPediatric intensive care unit survivorsTaiwan

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