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"Deeds not words": the forgotten class
1Division of Experimental Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB20QQ, UK. Bernadette.jenner@nhs.net.
Journal of Human Hypertension
|July 20, 2024
Summary
This essay argues for new antihypertensive drugs tailored to women. It highlights unmet needs in hypertension research and clinical trials for this demographic.
Area of Science:
- Cardiovascular Research
- Pharmacology
- Clinical Trials
Background:
- Sir Stanley Peart significantly advanced understanding of blood pressure regulation.
- His work included research on noradrenaline, angiotensin, and renin.
- The British and Irish Hypertension Society hosts an annual essay competition in his honor.
Purpose of the Study:
- To explore the need for novel antihypertensive drug classes.
- To address the specific needs of women with hypertension.
- To encourage greater female participation in clinical trials.
Main Methods:
- Analysis of current antihypertensive drug development.
- Review of unmet needs in hypertensive women.
- Proposal for a "forgotten class" of antihypertensives.
Main Results:
- Current antihypertensive treatments may not adequately address women's needs.
- Women are underrepresented in hypertension clinical trials.
- A new class of antihypertensives specifically for women is proposed.
Conclusions:
- There is a critical need for new antihypertensive drug classes.
- Focusing on women's unique physiological needs is essential.
- Increased female participation in trials will drive development of fit-for-purpose therapies.
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