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Published on: April 23, 2017
Polypeptide-based multilayer nanoarchitectures: Controlled assembly on planar and colloidal substrates for biomedical
Maria Angela Motta1, Lucinda Mulko2, Edurne Marin3
1POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizabal 3, 20018 Donostia-San Sebastián, Spain; Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, Bilbao School of Engineering, University of the Basque Country (UPV/EHU), Plaza Torres Quevedo 1, 48013 Bilbao, Spain.
Polypeptides are versatile building blocks for layer-by-layer (LbL) assembly in nanomedicine. This review highlights their use in tissue engineering and drug delivery, focusing on strategies to enhance multilayer stability for advanced biomedical applications.
Area of Science:
- Nanomedicine
- Biomaterials Science
- Polymer Chemistry
Background:
- Polypeptides offer biocompatibility, biodegradability, and functionality, making them ideal for nanomedicine.
- Their supramolecular organization facilitates use in layer-by-layer (LbL) assembly for nanoarchitectures.
- LbL technique enables fabrication of sophisticated multilayer films with diverse biomedical applications.
Purpose of the Study:
- To review the application of polypeptides in LbL nanoarchitectures for tissue engineering and drug delivery.
- To highlight polypeptide characteristics and strategies for enhancing multilayer film stability.
- To discuss the role of polypeptides in advanced nanomedical systems.
Main Methods:
- Layer-by-layer (LbL) assembly utilizing polypeptides as building blocks.
- Fabrication of multilayer films and nanoarchitectures on planar or colloidal templates.
- Cross-linking strategies to improve stability and stiffness of polypeptide-based structures.
Main Results:
- Polypeptides in LbL assemblies show promise for tissue engineering (cell adhesion, growth, differentiation) and antimicrobial coatings.
- LbL polypeptide structures are crucial for controlled drug delivery, ensuring payload retention and release.
- Polypeptides facilitate high-efficiency adsorption of genetic material and influence intracellular uptake pathways.
Conclusions:
- Polypeptide-based LbL nanoarchitectures are highly adaptable for tissue engineering and drug delivery.
- Cross-linking is essential for enhancing the stability and mechanical properties of these biomedical constructs.
- Future directions include stimuli-responsive polypeptide systems and theranostics for personalized medicine.
