Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure
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View abstract on PubMed
Summary
This summary is machine-generated.Childhood maltreatment duration, not severity, impacts brain connectivity. Longer exposure to maltreatment is linked to altered default-mode network (DMN) connectivity, potentially impairing information processing.
Area Of Science
- Neuroscience
- Psychiatry
- Mental Health Research
Background
- Childhood maltreatment (CM) is linked to altered default-mode network (DMN) connectivity in various mental disorders.
- Research on CM's impact on DMN connectivity, considering both severity and duration, is limited, especially in transdiagnostic samples.
Purpose Of The Study
- To investigate the transdiagnostic effects of childhood maltreatment severity and duration on resting-state DMN connectivity.
- To examine how CM influences inter-network connectivity within the DMN and with other brain networks.
Main Methods
- Resting-state functional magnetic resonance imaging (fMRI) was used to analyze DMN connectivity in 128 participants with PTSD, MDD, SSD, and healthy controls.
- Region-of-interest (ROI-to-ROI) and Seed-to-Voxel analyses were performed, with CM assessed retrospectively as a predictor in regression models.
Main Results
- CM duration, not severity, was associated with altered connectivity between DMN nodes and visual network regions.
- Increased connectivity was observed between the precuneus, visual, and sensory-motor regions with longer CM duration.
Conclusions
- Longer duration of childhood maltreatment is associated with altered brain connectivity, specifically impacting the default-mode network's interaction with visual and sensory-motor regions.
- These connectivity changes may reflect impaired information transfer, worsening with increased duration of CM exposure.
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