Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

224
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
224

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment-characteristic brain structural changes in depression: A multi-center longitudinal observational study.

Journal of affective disorders·2026
Same author

Correlations between white matter hyperintensities, magnetic resonance imaging findings, and cognition in the oldest old: a multimodal cross-sectional study.

GeroScience·2026
Same author

Differential effects of cognitive behavioral therapy and pharmacotherapy on cognitive function in patients with major depressive disorder: A propensity-weighted longitudinal study.

Journal of affective disorders·2026
Same author

Gray and White matter microstructural alterations in major depressive disorder: a multi-center diffusion imaging study.

Translational psychiatry·2026
Same author

Hierarchical Brain Dynamics Associated With Remission From Major Depression Across Diverse Therapeutic Modalities.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Pareidolic Illusions and Associated Lower Regional Gray Matter Volumes in Community-Dwelling Older Adults Without Dementia: The Arakawa 65+ Study.

International journal of geriatric psychiatry·2025

Related Experiment Video

Updated: Jun 20, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K

Glymphatic system dysfunction in mood disorders: Evaluation by diffusion magnetic resonance imaging.

Ryo Ueda1, Bun Yamagata2, Richi Niida2

  • 1Office of Radiation Technology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Neuroscience
|July 21, 2024
PubMed
Summary

Bipolar disorder is linked to impaired brain waste clearance via the glymphatic system. Longer illness duration worsens this glymphatic system dysfunction, impacting brain interstitial fluid dynamics.

Keywords:
Bipolar disorderDiffusion tensor imagingGlymphatic systemMagnetic resonance imagingWhite matter

More Related Videos

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.3K

Related Experiment Videos

Last Updated: Jun 20, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.3K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • The glymphatic system clears waste from the brain.
  • Its dysfunction is implicated in various pathologies, including affective disorders.
  • The specific relationship between bipolar disorder and glymphatic function requires further investigation.

Purpose of the Study:

  • To investigate the interplay between bipolar disorder and the glymphatic system.
  • To assess brain interstitial fluid dynamics using advanced MRI techniques.
  • To correlate glymphatic function with clinical parameters in bipolar disorder patients.

Main Methods:

  • Utilized diffusion tensor imaging to calculate the along the perivascular space (ALPS) index in 58 bipolar disorder patients and 66 controls.
  • Performed covariance analysis and partial correlation analyses with age and sex as covariates.
  • Employed free-water imaging to analyze white matter alterations and their correlation with clinical scores.

Main Results:

  • A significant negative correlation was found between the ALPS index and illness duration in bipolar disorder patients.
  • Elevated free-water index in white matter, particularly the corpus callosum, was observed in the bipolar cohort.
  • Free-water-corrected radial diffusivity correlated positively with depression scores in relevant brain regions.

Conclusions:

  • Protracted bipolar disorder exacerbates glymphatic system dysregulation.
  • Impaired glymphatic clearance and white matter changes are associated with bipolar disorder.
  • These findings highlight the glymphatic system as a potential therapeutic target in bipolar disorder.