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Causal relationships between immune cell phenotypes and lung adenocarcinoma: A bidirectional two-sample Mendelian
Bowen Li1, Zhicheng Huang1, Yadong Wang1
1Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Thoracic Cancer
|July 21, 2024
Summary
This study reveals causal links between specific immune cell phenotypes and lung adenocarcinoma (LUAD). Findings suggest immune cell changes may contribute to LUAD development and vice versa, offering potential early screening biomarkers.
Area of Science:
- Immunology
- Oncology
- Genetics
Background:
- Lung adenocarcinoma (LUAD) is strongly linked to the immune system, but causal relationships between immune cell alterations and LUAD remain unclear.
- Limited research hinders understanding of how LUAD impacts immune cell phenotypes.
Purpose of the Study:
- To investigate potential causal relationships between 731 immune cell phenotypes and LUAD using Mendelian randomization.
- To identify immune cell characteristics that may influence LUAD development.
Main Methods:
- Bidirectional two-sample Mendelian randomization (MR) analysis.
- Examination of four immune phenotype types: absolute counts, relative counts, median fluorescence intensities (MFIs), and morphological parameters.
- Validation through heterogeneity, horizontal pleiotropy, and leave-one-out analyses.
Main Results:
- Identified 26 immune cell characteristics associated with LUAD occurrence, including memory B cells, IgD-CD38br cells, CD4+ regulatory T cells (Tregs), and plasmacytoid dendritic cells (DCs).
- Reverse MR revealed LUAD influences 16 immune cell traits, affecting surface markers, cell types, antigen presentation, and immune activation.
Conclusions:
- Established causal links between specific immune cell phenotypes and LUAD.
- Findings suggest potential oncogenic states and provide candidates for early LUAD screening biomarkers.
