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NLR, MLR, and PLR are adverse prognostic variables for sleeve lobectomy within non-small cell lung cancer

  • 0Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Thoracic Cancer +

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July 22, 2024

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July 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Peripheral blood neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet lymphocyte ratio (PLR) can predict survival and recurrence in non-small cell lung cancer (NSCLC) patients undergoing sleeve lobectomy (SL). These simple blood tests offer a cost-effective prognostic tool for NSCLC management.

Area Of Science

  • Oncology
  • Thoracic Surgery
  • Diagnostic Biomarkers

Background

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality.
  • Sleeve lobectomy (SL) is a lung-sparing surgical option for central-type NSCLC.
  • Identifying reliable prognostic indicators for NSCLC patients undergoing SL is crucial for treatment planning and patient management.

Purpose Of The Study

  • To evaluate the prognostic value of peripheral blood neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet lymphocyte ratio (PLR) in predicting survival and recurrence.
  • To assess the utility of these ratios as convenient and cost-effective biomarkers in patients with central-type NSCLC undergoing SL.

Main Methods

  • Retrospective analysis of clinical data from 146 patients with NSCLC who underwent SL.
  • Determination of NLR, MLR, and PLR levels and establishment of threshold points using receiver operating characteristic (ROC) curve analysis.
  • Kaplan-Meier survival analysis and univariate/multivariate Cox proportional hazards models (COX) were used to assess prognostic significance.

Main Results

  • Significant differences in overall survival (OS) and disease-free survival (DFS) were observed based on NLR, MLR, and PLR cutoff values (p < 0.05 for all).
  • Univariate COX analysis indicated that NLR, MLR, and PLR were significantly correlated with OS.
  • Multivariate COX analysis identified NLR as an independent predictor of OS, while pN stage, NLR, MLR, and PLR were associated with DFS, with pN stage being an independent predictor of DFS.

Conclusions

  • Neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet lymphocyte ratio (PLR) are valuable predictors of survival and recurrence in patients with central-type NSCLC undergoing SL.
  • These peripheral blood indicators offer a practical and economical approach for prognostic assessment in NSCLC patients.
  • The findings support the integration of these simple blood-based markers into routine clinical practice for improved NSCLC patient management.

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